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Thursday 01 April, 2010 |
 Sanguinarine also Transmitted Through Milk The detection techniques developed later in London showed that the milk of goats fed on argemone leaves contained sanguinarine and other alkaloids. This transmission experiment was repeated in London on a group of lactating rabbits that were injected with sanguinarine and subsequently milked. Sanguinarine was detected from several, even 1 ml, samples of such milk. The rabbit milk also showed a green fluorescing metabolite of sanguinarine which was found to be identical with synthetically prepared benz(c)acridine, the metabolic conversion taking place in the liver (Hakim et al., 1961 b). As benz(c)acridine has the basic molecular structure of a series of the most virulent of experimental carcinogenic hydrocarbons, according to Prof. Lacassagne from the Radium Institute at Paris, I applied both sanguinarine and benz(c)acridine on the skin of a group of mice, using his method. I also implanted paraffin pellets containing these substances into the bladder of rats, and found after several months that both substances produced, papillomas and carcinomas in mice and rats. The goat and rabbit experiments clearly proved that lactating animals if fed on sanguinarine-containing plants, could transmit glaucoma-inducing sanguinarine and cancer-inducing benz(c)acridine in their milk.Other news for Thursday 01 April, 2010 View all news for Thursday 01 April, 2010 on one page |
